A placebo-controlled study of the doses and efficacy of Lentinula edodes mycelia for oxaliplatin-induced peripheral neuropathy in colorectal cancer

A placebo-controlled study of the doses and efficacy of Lentinula edodes mycelia for oxaliplatin-induced peripheral neuropathy in colorectal cancer

IntroductionPreclinical studies have demonstrated the potential of Lentinula edodes mycelium (L.E.M.) extract for managing oxaliplatin-induced peripheral neuropathy (OIPN). The efficacy and optimal dosage of L.E.M. for OIPN remain uncertain. We evaluated the efficacy and safety as well as the optima...

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Main Authors: Shogen Boku, Hironaga Satake, Seiichiro Mitani, Kiyoshi Maeda, Toshihiro Kudo, Toshifumi Yamaguchi, Tatsuya Takagi, Hisato Kawakami
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
chemotherapy-induced peripheral neuropathy
colorectal cancer
Lentinula edodes mycelia
L.E.M.
oxaliplatin
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1577848/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1577848/full

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