Neuronal CD47 induces behavioral alterations and ameliorates microglial synaptic pruning in wild-type and Alzheimer’s mouse models

Neuronal CD47 induces behavioral alterations and ameliorates microglial synaptic pruning in wild-type and Alzheimer’s mouse models

Abstract Background Microglia are brain-resident macrophages that play a crucial role in synapse pruning during the development and progression of various neuropsychiatric disorders, including autism spectrum disorder (ASD) and Alzheimer’s disease (AD). Mechanistically, CD47 protein acts as a potent...

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Bibliographic Details
Main Authors: Wenjie Hu, Mengting Chen, Yuxue Lin, Hui Zhang, Li Sun, Wei Shao, Yuping Ye, Yujie Cheng, Shanshan Zhou, Panpan Hu, Xingqi Wu, Yin Xu, Kai Wang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cell & Bioscience
Subjects:
CD47
Microglia
Alzheimer’s disease
Autism spectrum disorder
Neuron-microglia interactions
Online Access:https://doi.org/10.1186/s13578-025-01378-x
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https://doi.org/10.1186/s13578-025-01378-x

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