Linking TLR-7 Signaling to Downregulation of Placental P-Glycoprotein: Implications for Fetal Drug Exposure

Linking TLR-7 Signaling to Downregulation of Placental P-Glycoprotein: Implications for Fetal Drug Exposure

<b>Background/Objectives:</b> Activation of the Toll-like receptor 7 (TLR-7) plays an important role in the pathogenesis of many autoimmune diseases and viral infections. Although we have previously observed inflammation-mediated dysregulation of placental transporters, the role of TLR-7...

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Bibliographic Details
Main Authors: Mario Riera-Romo, Eliza R McColl, Micheline Piquette-Miller
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceutics
Subjects:
viral infections
autoimmune diseases
TLR-7
inflammation
transporters
P-glycoprotein
Online Access:https://www.mdpi.com/1999-4923/17/6/741
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