Design and in vitro evaluation of novel tetrazole derivatives of dianisidine as anticancer agents targeting Bcl-2 apoptosis regulator

Abstract This study examines the synthesis and biological evaluation of novel tetrazole derivatives of 3,3′-dimethoxybenzidine as potential anticancer agents, focusing on their cytotoxic, apoptotic, and anti-inflammatory properties. Ten derivatives were synthesized using thioureas as precursors, cha...

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Bibliographic Details
Main Authors: Wioletta Olejarz, Karol Sadowski, Piotr Roszkowski, Anna Bielenica, Maciej Wiśniewski, Marta Struga, Daniel Szulczyk
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-02781-7
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