Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury

Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury

Abstract Sepsis-associated acute kidney injury (SA-AKI) portends severe health burden due to significant morbidity and mortality, while early diagnosis remains challenging. In this study, proximity-dependent barcoding assay (PBA) is established to profile the surface proteome of single urinary extra...

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Main Authors: Ning Li, Tao-Tao Tang, Menglei Gu, Yu-Qi Fu, Wei-Wei Qian, Nan Nan Ma, An-Ran Shen, Tingting Zhu, Run-Bo Huo, Tao Zhang, Jian-Feng Xie, Lu Zhang, Bi-Cheng Liu, Lin-Li Lv
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62229-4
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https://doi.org/10.1038/s41467-025-62229-4

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