2-Deoxy-D-Glucose and ES-936 sensitize cancer- but not normal cells to both low- and high LET irradiation

2-Deoxy-D-Glucose and ES-936 sensitize cancer- but not normal cells to both low- and high LET irradiation

IntroductionMetabolic differences of normal- and cancer cells represent an important target for the development of novel cancer treatment strategies. Given that radiotherapy constitutes one of the primary treatment modalities for solid cancers, the targeting of cancer cell metabolism to enhance thei...

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Bibliographic Details
Main Authors: Katja Kratz, Henrieke Förster, Kira Vogel, Marco Durante, Burkhard Jakob
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
radiotherapy
high-LET
cancer
metabolism
DNA-repair
carbon-ions
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1633299/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1633299/full

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