Quantitative Immunofluorescence Mapping of HSP70’s Neuroprotective Effects in FUS-ALS Mouse Models

Quantitative Immunofluorescence Mapping of HSP70’s Neuroprotective Effects in FUS-ALS Mouse Models

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, often linked to mutations in the FUS gene, leading to toxic protein aggregates. This study investigates the role of HSP70, a molecular chaperone, in mitigating neurodegeneration in FUS-ALS mouse models. Using quantitativ...

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Bibliographic Details
Main Authors: Gennadii A. Piavchenko, Ksenia S. Pokidova, Egor A. Kuzmin, Artem A. Venediktov, Ilya Y. Izmailov, Igor V. Meglinski, Sergey L. Kuznetsov
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Applied Sciences
Subjects:
heat shock proteins
HSP70
HSPA1A
neurodegeneration
primary motor cortex
amyotrophic lateral sclerosis
Online Access:https://www.mdpi.com/2076-3417/14/24/11614
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https://www.mdpi.com/2076-3417/14/24/11614

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