Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation

Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation

Summary: Toxicogenomic data provide key insights into molecular mechanisms underlying drug-induced organ toxicities. To simplify transcriptomic data interpretation, we applied weighted gene co-expression network analysis (WGCNA) to rat kidney transcriptomics data from TG-GATEs (TG) and DrugMatrix (D...

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Main Authors: Steven J. Kunnen, Giulia Callegaro, Jeffrey J. Sutherland, Panuwat Trairatphisan, Hugo W. van Kessel, Lukas S. Wijaya, Git Chung, Keith Pye, Keith M. Goldstein, Claire R. Teague, Ciaran P. Fisher, Julio Saez-Rodriguez, Colin Brown, Susan A. Elmore, Kathleen M. Heinz-Taheny, James L. Stevens, Bob van de Water
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
biocomputational method
data processing in systems biology
transcriptomics
model organism
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225012398
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