A Hedgehog–Foxf axis coordinates dental follicle-derived alveolar bone formation

A Hedgehog–Foxf axis coordinates dental follicle-derived alveolar bone formation

Abstract The alveolar bone is a specialized mineralized structure supporting the lifelong functionality of the tooth in mastication. The alveolar bone develops from the dental follicle (DF) during tooth root formation due to deliberate epithelial–mesenchymal interactions. However, how DF progenitor...

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Main Authors: Mizuki Nagata, Gaurav T. Gadhvi, Taishi Komori, Yuki Arai, Chiaki Tsutsumi-Arai, Angel Ka Yan Chu, Seth N. Nye, Yuntao Yang, Shion Orikasa, Akira Takahashi, Peter Carlsson, W. Jim Zheng, Joshua D. Welch, Noriaki Ono, Wanida Ono
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61050-3
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https://doi.org/10.1038/s41467-025-61050-3

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