Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model
Abstract Cryptococcus neoformans is considered a critical fungal pathogen by the World Health Organization and developing a vaccine for cryptococcosis is a top priority. Here, we employed mRNAs encoding an antigen(s) packaged in lipid nanoparticles (LNPs) to develop vaccines for cryptococcosis. Rema...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | npj Vaccines |
| Online Access: | https://doi.org/10.1038/s41541-025-01079-z |
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| _version_ | 1823863265359298560 |
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| author | Yeqi Li Suresh Ambati Richard B. Meagher Xiaorong Lin |
| author_facet | Yeqi Li Suresh Ambati Richard B. Meagher Xiaorong Lin |
| author_sort | Yeqi Li |
| collection | DOAJ |
| description | Abstract Cryptococcus neoformans is considered a critical fungal pathogen by the World Health Organization and developing a vaccine for cryptococcosis is a top priority. Here, we employed mRNAs encoding an antigen(s) packaged in lipid nanoparticles (LNPs) to develop vaccines for cryptococcosis. Remarkably, when coupled with capsule adjuvant, vaccination with CDA1-LNPs protected the vast majority of mice from the otherwise lethal cryptococcosis. These results support the promise of mRNA-LNP vaccines against fungal diseases. |
| format | Article |
| id | doaj-art-46b721344144445498a7895ada06b798 |
| institution | Kabale University |
| issn | 2059-0105 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Vaccines |
| spelling | doaj-art-46b721344144445498a7895ada06b7982025-02-09T12:11:06ZengNature Portfolionpj Vaccines2059-01052025-02-011011710.1038/s41541-025-01079-zDeveloping mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine modelYeqi Li0Suresh Ambati1Richard B. Meagher2Xiaorong Lin3Department of Microbiology, University of GeorgiaDepartment of Genetics, University of GeorgiaDepartment of Genetics, University of GeorgiaDepartment of Microbiology, University of GeorgiaAbstract Cryptococcus neoformans is considered a critical fungal pathogen by the World Health Organization and developing a vaccine for cryptococcosis is a top priority. Here, we employed mRNAs encoding an antigen(s) packaged in lipid nanoparticles (LNPs) to develop vaccines for cryptococcosis. Remarkably, when coupled with capsule adjuvant, vaccination with CDA1-LNPs protected the vast majority of mice from the otherwise lethal cryptococcosis. These results support the promise of mRNA-LNP vaccines against fungal diseases.https://doi.org/10.1038/s41541-025-01079-z |
| spellingShingle | Yeqi Li Suresh Ambati Richard B. Meagher Xiaorong Lin Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model npj Vaccines |
| title | Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model |
| title_full | Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model |
| title_fullStr | Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model |
| title_full_unstemmed | Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model |
| title_short | Developing mRNA lipid nanoparticle vaccine effective for cryptococcosis in a murine model |
| title_sort | developing mrna lipid nanoparticle vaccine effective for cryptococcosis in a murine model |
| url | https://doi.org/10.1038/s41541-025-01079-z |
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