Optimization of bile preparation for liquid biopsy in cholangiocarcinoma focusing on circulating tumor DNA and protein stability

Optimization of bile preparation for liquid biopsy in cholangiocarcinoma focusing on circulating tumor DNA and protein stability

Abstract Liquid biopsy using bile offers a promising non-invasive approach for molecular analysis in cholangiocarcinoma (CCA). However, the stability of key biomarkers, such as proteins and circulating DNA (ctDNA), at room temperature has not been fully elucidated. This study investigates the tempor...

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Bibliographic Details
Main Authors: Jin-Yi Han, Keun Soo Ahn, Min Jae Kim, Tae-Seok Kim, Yong Hoon Kim, Kwang Bum Cho, Koo Jeong Kang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Standard operating procedures (SOPs)
Cholangiocarcinoma (CCA)
Liquid biopsy
Bile
Circulating tumor DNA (ctDNA)
Protein stability
Online Access:https://doi.org/10.1038/s41598-025-96170-9
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https://doi.org/10.1038/s41598-025-96170-9

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