Hyaluronidase: structure, mechanism of action, diseases and therapeutic targets

Hyaluronidase: structure, mechanism of action, diseases and therapeutic targets

Abstract Hyaluronidase (HAase), a family of enzymes critical for regulating physiological and pathological states, catalyzes the degradation of hyaluronic acid (HA), a key component of the extracellular matrix (ECM). By modulating ECM composition and cellular signaling pathways, HAase plays a pivota...

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Bibliographic Details
Main Authors: Jiamin Lu, Zheng Zhao, Lingli Pan, Hui Wu, Shibing Wang, Xiangmin Tong, Shenghao Wu
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Molecular Biomedicine
Subjects:
Hyaluronidase
Hyaluronic acid
Tumor microenvironment
Extracellular matrix
Tumor immunotherapy
Online Access:https://doi.org/10.1186/s43556-025-00299-y
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https://doi.org/10.1186/s43556-025-00299-y

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