Integrated transcriptomic, proteomic, and metabolomic analysis unveils key roles of protein and nucleic acid interactions in diabetic ulcer pathogenesis

Integrated transcriptomic, proteomic, and metabolomic analysis unveils key roles of protein and nucleic acid interactions in diabetic ulcer pathogenesis

BackgroundDiabetes mellitus significantly increases the risk of complications, particularly diabetic foot ulcers (DFUs). However, the underlying mechanism remains unclear. This study aimed to assess the overall therapeutic approach in diabetic ulcers.MethodsUsing integrated high-throughput multi-omi...

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Bibliographic Details
Main Authors: Yongpan Lu, Hairui Gao, Sen Wang, Han Xu, Zhiyu Chen, Yixin Zhang, Yunfei Gu, Xiaomei Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Endocrinology
Subjects:
diabetic foot ulcers
transcriptomics
proteomics
metabolomics
multi-omics
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1574858/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1574858/full

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