Inhibition of autophagy as a novel treatment for neurofibromatosis type 1 tumors

Inhibition of autophagy as a novel treatment for neurofibromatosis type 1 tumors

Neurofibromatosis type 1 (NF1) is a genetic disorder caused by mutation of the NF1 gene that is associated with various symptoms, including the formation of benign tumors, called neurofibromas, within nerves. Drug treatments are currently limited. The mitogen‐activated protein kinase kinase (MEK) in...

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Bibliographic Details
Main Authors: Megan Stevens, Yuanli Wang, Stephanie J. Bouley, Torrey R. Mandigo, Aditi Sharma, Sonali Sengupta, Amy Housden, Norbert Perrimon, James A. Walker, Benjamin E. Housden
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Molecular Oncology
Subjects:
autophagy
Drosophila
drug repurposing
neurofibromatosis type 1
synthetic lethality
Online Access:https://doi.org/10.1002/1878-0261.13704
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https://doi.org/10.1002/1878-0261.13704

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