A Single-Cell Transcriptome Atlas of Epithelial Subpopulations in HPV-Positive and HPV-Negative Head and Neck Cancers

A Single-Cell Transcriptome Atlas of Epithelial Subpopulations in HPV-Positive and HPV-Negative Head and Neck Cancers

Persistent infection with HPV causes nearly 5% of all cancers worldwide, including cervical and oropharyngeal cancers. Compared to HPV-negative (HPV−) head and neck squamous cell carcinomas (HNSCCs), HPV-positive (HPV+) HNSCCs exhibit a significantly improved treatment response; however, established...

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Bibliographic Details
Main Authors: Mary C. Bedard, Cosette M. Rivera-Cruz, Tafadzwa Chihanga, Andrew VonHandorf, Alice L. Tang, Chad Zender, Matthew T. Weirauch, Robert Ferris, Trisha M. Wise-Draper, Mike Adam, Susanne I. Wells
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Viruses
Subjects:
human papillomavirus
HPV
head and neck cancer
HNSCC
single-cell transcriptomics
scRNAseq
Online Access:https://www.mdpi.com/1999-4915/17/4/461
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