NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis

NANS suppresses NF-κB signaling to promote ferroptosis by perturbing iron homeostasis

Summary: Metastatic colorectal cancer (CRC) cells endure survival challenges, including treatment-induced ferroptosis. While adaptation to ferroptosis stress facilitates metastasis, reciprocal regulatory mechanisms remain unclear. Here, a CRISPR-Cas9 screen identifies N-acetylneuraminate synthase (N...

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Bibliographic Details
Main Authors: Ziyang Wang, Yuqin Di, Lvlan Ye, Wenzheng Fang, Xiangqiong Wen, Xiang Zhang, Jiale Qin, Youpeng Wang, Kunhua Hu, Zhenxin Zhu, Weiling He, Ying Chen
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725004723
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