NMDA Receptors Coordinate Metabolic Reprogramming and Mitophagy in Schwann Cells to Promote Peripheral Nerve Regeneration

NMDA Receptors Coordinate Metabolic Reprogramming and Mitophagy in Schwann Cells to Promote Peripheral Nerve Regeneration

Schwann cells (SCs) are indispensable for peripheral nerve regeneration, yet the mechanisms enabling their metabolic adaptation to meet the energetic demands of axonal repair remain elusive. Here, we identify N-methyl-D-aspartate (NMDA) receptors as central regulators of SC metabolic plasticity. In...

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Main Authors: Fangzhen Shan, Xiaoying Yao, Qingqing Zhang, Ruolin Li, Lingmeng Kong, Qian Zheng, Nannan Zhang, Yuzhong Wang
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2025-01-01
Series:Research
Online Access:https://spj.science.org/doi/10.34133/research.0825
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https://spj.science.org/doi/10.34133/research.0825

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