Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates

Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates

Abstract Approaches for the discovery of molecular glues remain limited. Here we report a phenotypic screening approach in which cytotoxins whose mechanisms require ubiquitination show a gain of viability following pharmacological inhibition of the Ubiquitin-like modifier activating enzyme (UBA1/UAE...

Full description

Saved in:
Bibliographic Details
Main Authors: Marc A. Scemama de Gialluly, Anthony R. Allen, Elijah H. Hayes, Patrick Zhuang, Ralston B. Goldfarb, Amanda N. Farrar, Yuriy Fedorov, Drew J. Adams
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61818-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41467-025-61818-7

Similar Items