Pirfenidone Prevents Myocarditis by Restoring Metabolic Hormone Levels in a Mouse MASH Model and its Effect on H9c2 Myoblast Viability under Glucolipotoxicity

Introduction and Objectives: Obesity, global epidemic, can cause metabolic dysfunction-associated steatohepatitis (MASH) and cardiovascular diseases. Pirfenidone (PFD) has anti-inflammatory and anti-fibrotic properties. We investigated the effects of PFD on metabolic hormones expression and myocardi...

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Main Authors: Daniel López-Cifuentes, Ana S. Sandoval-Rodríguez, Ángel O. Vázquez-Esqueda, Jonathan S. Rodríguez-Sanabria, Juan Armendáriz-Borunda, Jorge Gutiérrez-Cuevas
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Annals of Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268125000675
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