Dual-targeting and steric hindrance resolution in HER2 IHC: a novel approach to improve diagnostic sensitivity

Dual-targeting and steric hindrance resolution in HER2 IHC: a novel approach to improve diagnostic sensitivity

Abstract Background The HER2 immunohistochemistry (IHC) test is an essential method for detecting breast cancer (BC) and plays a pivotal role in guiding personalized treatment strategies. However, inconsistencies persist among different pathologists using IHC, especially for HER2-low and HER2-negati...

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Bibliographic Details
Main Authors: Li Luo, Xi Zhang, Linqiong Chen, Zhuohan Chen, Yuchen Wang, Kaihao Huang, Xiaoyun Lin, Hongxiang Zhu, Wangqi Du
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
HER2
Breast cancer
IHC
Steric hindrance
Diagnostic sensitivity
Online Access:https://doi.org/10.1186/s12885-025-14553-7
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https://doi.org/10.1186/s12885-025-14553-7

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