Early emergence of motivational and hedonic feeding deficits in the TgF344-AD rat model of Alzheimer’s disease

IntroductionAlzheimer’s disease (AD) is characterized by progressive cognitive decline and has a long prodromal phase during which subclinical cognitive deficits and neuropsychiatric symptoms may begin to emerge. Apathy, defined as a lack of motivation or volition, is increasingly recognized as a co...

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Bibliographic Details
Main Authors: Sean B. Ostlund, Grace Chen, Alisa Kosheleff, Lindsay M Lueptow, Irina Zhuravka, Sally A. Frautschy, Hoa A. Lam, Nigel T. Maidment
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Aging Neuroscience
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Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1572956/full
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