GRA12 is a common virulence factor across Toxoplasma gondii strains and mouse subspecies

Abstract Toxoplasma gondii parasites exhibit extraordinary host promiscuity owing to over 250 putative secreted proteins that disrupt host cell functions, enabling parasite persistence. However, most of the known effector proteins are specific to Toxoplasma genotypes or hosts. To identify virulence...

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Bibliographic Details
Main Authors: Francesca Torelli, Simon Butterworth, Eloise Lockyer, Ana N. Matias, Franziska Hildebrandt, Ok-Ryul Song, Jennifer Pearson-Farr, Moritz Treeck
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58876-2
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