INHBA+ macrophages and Pro-inflammatory CAFs are associated with distinctive immunosuppressive tumor microenvironment in submucous Fibrosis-Derived oral squamous cell carcinoma

INHBA+ macrophages and Pro-inflammatory CAFs are associated with distinctive immunosuppressive tumor microenvironment in submucous Fibrosis-Derived oral squamous cell carcinoma

Abstract Transcriptomic and metabolic profiles of tumor cells and stromal cells in oral squamous cell carcinoma (OSCC)-derived from oral submucosal fibrosis (OSF) (ODSCC) have been reported. However, the complex intercellular regulatory network within the tumor immunosuppressive microenvironment (TI...

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Bibliographic Details
Main Authors: Simin Zhao, Yu Zhang, Xiaoqin Meng, Ye Wang, Yahui Li, Hao Li, Xingyu Zhao, Pishan Yang, Shaopeng Liu, Chengzhe Yang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Cancer
Subjects:
Oral squamous cell carcinoma
Submucosal fibrosis
Inhibin subunit beta A
Immunosuppressive microenvironment
Macrophage
Online Access:https://doi.org/10.1186/s12885-025-14261-2
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https://doi.org/10.1186/s12885-025-14261-2

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