ASH1L in Hepatoma Cells and Hepatic Stellate Cells Promotes Fibrosis‐Associated Hepatocellular Carcinoma by Modulating Tumor‐Associated Macrophages

ASH1L in Hepatoma Cells and Hepatic Stellate Cells Promotes Fibrosis‐Associated Hepatocellular Carcinoma by Modulating Tumor‐Associated Macrophages

Abstract Hepatocellular carcinoma (HCC) often occurs in the context of fibrosis or cirrhosis. Methylation of histone is an important epigenetic mechanism, but it is unclear whether histone methyltransferases are potent targets for fibrosis‐associated HCC therapy. ASH1L, an H3K4 methyltransferase, is...

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Main Authors: Yuyang Du, Shasha Wu, Shaoyan Xi, Wei Xu, Liangzhan Sun, Jingsong Yan, Han Gao, Yanchen Wang, Jingyi Zheng, Fenfen Wang, Hui Yang, Dan Xie, Xi Chen, Xijun Ou, Xin‐Yuan Guan, Yan Li
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
ASH1L
fibrosis
hepatic stellate cells (HSCs)
hepatocellular carcinoma (HCC)
macrophage
Online Access:https://doi.org/10.1002/advs.202404756
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https://doi.org/10.1002/advs.202404756

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