Selective retinoid X receptor agonism promotes functional recovery and myelin repair in experimental autoimmune encephalomyelitis

Selective retinoid X receptor agonism promotes functional recovery and myelin repair in experimental autoimmune encephalomyelitis

Abstract Evidence that myelin repair is crucial for functional recovery in multiple sclerosis (MS) led to the identification of bexarotene (BXT). This clinically promising remyelinating agent activates multiple nuclear hormone receptor subtypes implicated in myelin repair. However, BXT produces unac...

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Main Authors: Gracious D. S. Kasheke, Basmah A. M. Hendy, Gabriel G. Dorighello, Nonthué A. Uccelli, Jean-David M. Gothié, Robyn J. Novorolsky, Madison J. Oulton, Jude Asainayagam, Adam I. Makarov, Kaitlyn S. Fraser, Vidyasagar Vuligonda, Martin E. Sanders, Timothy E. Kennedy, George S. Robertson
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Acta Neuropathologica Communications
Subjects:
Multiple sclerosis
Neural repair
Neuroprotection
Oligodendrocyte progenitor cell
Rehabilitation
Online Access:https://doi.org/10.1186/s40478-024-01904-x
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https://doi.org/10.1186/s40478-024-01904-x

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