Metabolic pathways mediating insulin resistance and gestational diabetes mellitus discovered by high-dimensional systematic Mendelian randomization

Metabolic pathways mediating insulin resistance and gestational diabetes mellitus discovered by high-dimensional systematic Mendelian randomization

Abstract Background Gestational diabetes mellitus (GDM), characterized by insulin resistance (IR) and β-cell dysfunction, is one of the most common complications of pregnancy with unmet needs of prevention methods. Objective To investigate the causal role of insulin resistance and metabolic pathways...

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Main Authors: Wei Chen, Mingjuan Luo, Jingyi Guo, Suna Wang, Dandan Yan, Xiaohui Feng, Yunting Huang, Tao Zeng, Li Shen, Rong Zhang, Jing Yan, Cheng Hu, Weituo Zhang, Xiangtian Yu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cardiovascular Diabetology
Subjects:
Gestational diabetes mellitus
Mendelian randomization
Insulin resistance
Adverse pregnancy outcome
Metabolic pathway
Online Access:https://doi.org/10.1186/s12933-025-02746-0
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https://doi.org/10.1186/s12933-025-02746-0

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