Investigating Irritability as a Potentially Causal Risk Pathway to Depression Using Two Genetically Informed Designs

Investigating Irritability as a Potentially Causal Risk Pathway to Depression Using Two Genetically Informed Designs

Background: Major depressive disorder (MDD) is heterogeneous, with diverse risk pathways leading to illness. Identifying causal routes to depression helps prioritize targets for early intervention and prevention strategies. Although irritability is associated with risk for later depression, this ass...

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Main Authors: Amy Shakeshaft, Olakunle Oginni, Joanna Martin, Charlotte A. Dennison, Olga Eyre, Ellen Leibenluft, Sebastian Lundström, Evie Stergiakouli, Henrik Larsson, Paul Lichtenstein, Argyris Stringaris, Lucy Riglin, Mark J. Taylor, Anita Thapar
Format: Article
Language:English
Published: Elsevier 2025-11-01
Series:Biological Psychiatry Global Open Science
Subjects:
Causal inference
Depression
Genetics
Irritability
Mendelian randomization
Twin study
Online Access:http://www.sciencedirect.com/science/article/pii/S266717432500120X
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