Structural insights into prolactin-releasing peptide receptor signaling and G-protein coupling selectivity

Structural insights into prolactin-releasing peptide receptor signaling and G-protein coupling selectivity

Summary: Prolactin-releasing peptide receptor (PrRPR), a notable member of the class A peptide-GPCR (G-protein-coupled receptor) family, regulates diverse physiology functions upon activation by PrRP. Herein, we reveal that PrRPR could engage with not only the Gq/11 pathway but also the Gi/o pathway...

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Main Authors: Zhangsong Wu, Chen Qiu, Yiming Liu, Xiaoyi Yan, Qiaohui Li, Shirui Jiang, Jun Xu, Xin Pan, Fang Ye, Zhiyi Zhang, Peiruo Ning, Binghao Zhang, Lezhi Xu, Bangning Cheng, Xufu Xiang, Chungen Qian, Yang Du, Geng Chen
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Cell Reports
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CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725001081
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http://www.sciencedirect.com/science/article/pii/S2211124725001081

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