Pre-mRNA processing factors differentially impact coordination between co-transcriptional cleavage and transcription termination

Pre-mRNA processing factors differentially impact coordination between co-transcriptional cleavage and transcription termination

Abstract Co-transcriptional cleavage and transcription termination are closely related processes during mRNA maturation, yet their coordination remains poorly understood due to difficulties in detecting these transient events. Here, we applied single-molecule nascent RNA sequencing to simultaneously...

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Main Authors: Xianhao Jin, Juzuo Li, Wenqin Lu, Xian Deng, Yanping Wei, Yi Shu, Bo Liu, Zhijian Liu, Yanping Long, Xinlong Zhu, Qili Fei, Yiji Xia, Qingshun Q. Li, Scott D. Michaels, Xiaofeng Cao, Michael Lenhard, Jixian Zhai
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62555-7
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https://doi.org/10.1038/s41467-025-62555-7

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