Adaptation by stochastic switching of a monostable genetic circuit in Escherichia coli

Adaptation by stochastic switching of a monostable genetic circuit in Escherichia coli

Abstract Stochastic switching is considered as a cost‐saving strategy for adaptation to environmental challenges. We show here that stochastic switching of a monostable circuit can mediate the adaptation of the engineered OSU12‐hisC Escherichia coli strain to histidine starvation. In this strain, th...

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Bibliographic Details
Main Authors: Saburo Tsuru, Nao Yasuda, Yoshie Murakami, Junya Ushioda, Akiko Kashiwagi, Shingo Suzuki, Kotaro Mori, Bei‐Wen Ying, Tetsuya Yomo
Format: Article
Language:English
Published: Springer Nature 2011-05-01
Series:Molecular Systems Biology
Subjects:
adaptation
gene regulation
monostability
stochastic switching
transciptome
Online Access:https://doi.org/10.1038/msb.2011.24
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https://doi.org/10.1038/msb.2011.24

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