Interferon-gamma-activated macrophages infected with Burkholderia cenocepacia process and present bacterial antigens to T-cells by class I and II major histocompatibility complex molecules

Interferon-gamma-activated macrophages infected with Burkholderia cenocepacia process and present bacterial antigens to T-cells by class I and II major histocompatibility complex molecules

Burkholderia cenocepacia is an emerging opportunistic pathogen for people with cystic fibrosis and chronic granulomatous disease. Intracellular survival in macrophages within a membrane-bound vacuole (BcCV) that delays acidification and maturation into lysosomes is a hallmark of B. cenocepacia infec...

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Main Authors: Roberto Rosales-Reyes, Paola Garza-Villafuerte, Daniela Vences-Vences, Daniel F. Aubert, Rubi Aca-Teutle, Vianney F. Ortiz-Navarrete, Laura C. Bonifaz, Julio Cesar Carrero-Sánchez, Alfonso Olivos-García, Miguel A. Valvano, José Ignacio Santos-Preciado
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Emerging Microbes and Infections
Subjects:
Burkholderia cepacia complex
T-cell activation
antigen processing
MIIC
Rab7
Type 6 secretion
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2020.1818632
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https://www.tandfonline.com/doi/10.1080/22221751.2020.1818632

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