C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation

C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation

Abstract Background In many tumors, the tumor suppressor TP53 is not mutated, but functionally inactivated. However, mechanisms underlying p53 functional inactivation remain poorly understood. SETD8 is the sole enzyme known to mono-methylate p53 on lysine 382 (p53K382me1), resulting in the inhibitio...

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Main Authors: Veronica Veschi, Francesco Verona, Sebastiano Di Bella, Alice Turdo, Miriam Gaggianesi, Simone Di Franco, Laura Rosa Mangiapane, Chiara Modica, Melania Lo Iacono, Paola Bianca, Ornella Roberta Brancato, Caterina D’Accardo, Gaetana Porcelli, Vincenzo Luca Lentini, Isabella Sperduti, Elisabetta Sciacca, Peter Fitzgerald, David Lopez-Perez, Pierre Martine, Kate Brown, Giuseppe Giannini, Ettore Appella, Giorgio Stassi, Matilde Todaro
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Cancer
Subjects:
SETD8
P53K382me1
Cancer stem cells
C1Q+ TPP1+ macrophages
IBD
CRC
Online Access:https://doi.org/10.1186/s12943-025-02293-y
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https://doi.org/10.1186/s12943-025-02293-y

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