Sex Differences of Brain Serotonin Synthesis in Patients with Irritable Bowel Syndrome Using α-[11C]methyl-L-tryptophan, Positron Emission Tomography and Statistical Parametric Mapping

BACKGROUND: Irritable bowel syndrome (IBS) is the most common functional bowel disorder and has a strong predominance in women. Recent data suggest that the brain may play an important role in the pathophysiology of IBS in the brain-gut axis. It is strongly suspected that serotonin (5-HT), a neurotr...

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Bibliographic Details
Main Authors: Akio Nakai, Yoshikata Kumakura, Michel Boivin, Pedro Rosa, Mirko Diksic, Doreen D’Souza, Kathryn Kersey
Format: Article
Language:English
Published: Wiley 2003-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2003/572127
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