Super-enhancers and efficacy of triptolide in small cell carcinoma of the ovary hypercalcemic type

Super-enhancers and efficacy of triptolide in small cell carcinoma of the ovary hypercalcemic type

Summary: Small cell carcinoma of the ovary-hypercalcemic type (SCCOHT) is a rare ovarian cancer affecting young females and is driven by the loss of both SWI/SNF ATPases SMARCA4 and SMARCA2. As loss of SWI/SNF alters enhancers, we hypothesized that super-enhancers, which regulate oncogene expression...

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Main Authors: Jessica D. Lang, William Selleck, Shawn Striker, Nicolle A. Hipschman, Rochelle Kofman, Anthony N. Karnezis, Felix K.F. Kommoss, Friedrich Kommoss, Jae Rim Wendt, Salvatore J. Facista, William P.D. Hendricks, Krystal A. Orlando, Patrick Pirrotte, Elizabeth A. Raupach, Victoria L. Zismann, Yemin Wang, David G. Huntsman, Bernard E. Weissman, Jeffrey M. Trent
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Molecular biology
Complex system biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422500029X
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