Targeting the thioredoxin system as a novel strategy against B‐cell acute lymphoblastic leukemia

Targeting the thioredoxin system as a novel strategy against B‐cell acute lymphoblastic leukemia

B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) is a genetically heterogeneous blood cancer characterized by abnormal expansion of immature B cells. Although intensive chemotherapy provides high cure rates in a majority of patients, subtypes harboring certain genetic lesions, such as MLL rea...

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Main Authors: Klaudyna Fidyt, Agata Pastorczak, Agnieszka Goral, Kacper Szczygiel, Wojciech Fendler, Angelika Muchowicz, Marcin Adam Bartlomiejczyk, Joanna Madzio, Julia Cyran, Agnieszka Graczyk‐Jarzynka, Eugene Jansen, Elzbieta Patkowska, Ewa Lech‐Maranda, Deepali Pal, Helen Blair, Anna Burdzinska, Piotr Pedzisz, Eliza Glodkowska‐Mrowka, Urszula Demkow, Karolina Gawle‐Krawczyk, Michal Matysiak, Magdalena Winiarska, Przemyslaw Juszczynski, Wojciech Mlynarski, Olaf Heidenreich, Jakub Golab, Malgorzata Firczuk
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Molecular Oncology
Subjects:
ALL
antioxidant enzymes
leukemia
oxidative stress
peroxiredoxin
thioredoxin
Online Access:https://doi.org/10.1002/1878-0261.12476
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https://doi.org/10.1002/1878-0261.12476

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