Spatially resolved atlas of breast cancer uncovers intercellular machinery of venular niche governing lymphocyte extravasation

Spatially resolved atlas of breast cancer uncovers intercellular machinery of venular niche governing lymphocyte extravasation

Abstract Breast cancers present intricate microenvironments comprising heterotypic cellular interactions, yet a comprehensive spatial map remained to be established. Here, we employed the DNA nanoball-based genome-wide in situ sequencing (Stereo-seq) to visualize the geospatial architecture of 30 pr...

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Main Authors: Xin Wang, Zhanyu Wang, Qijun Liao, Pei Yuan, Junpu Mei, Yin Zhang, Chao Wu, Xiyu Kang, Sufei Zheng, Chenxuan Yang, Jiaxiang Liu, Qingyao Shang, Jiangtao Li, Bingning Wang, Liangyu Li, Hui Liu, Weining Hu, Zhensheng Dong, Jie Zhao, Linying Wang, Tao Liu, Yusheng Den, Chengrui Wang, Lijuan Han, Qianjun Chen, Huanming Yang, Xun Xu, Jie He, Zhen Yue, Nan Sun, Xiaodong Fang, Jianming Ying
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58511-0
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https://doi.org/10.1038/s41467-025-58511-0

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