Glucocorticosteroid in Treatment of Severe Pneumonia
Airway diseases such as pneumonia constitute a major health burden on a global scale; untreated pneumonia may develop to severe pneumonia and consequently lead to to fatal episodes of mortality and morbidity. The balance between inflammatory mediators is key for the outcome of the pulmonary infectio...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/865635 |
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| _version_ | 1832551042521235456 |
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| author | Felinda Ariani Kaixiong Liu Zhang Jing Jieming Qu |
| author_facet | Felinda Ariani Kaixiong Liu Zhang Jing Jieming Qu |
| author_sort | Felinda Ariani |
| collection | DOAJ |
| description | Airway diseases such as pneumonia constitute a major health burden on a global scale; untreated pneumonia may develop to severe pneumonia and consequently lead to to fatal episodes of mortality and morbidity. The balance between inflammatory mediators is key for the outcome of the pulmonary infection; elimination of invading pathogen was marked by the release of cytokines and other inflammatory mediators from alveolar macrophages and glucocorticoid steroids (GCs) acting on the inflammatory component. Treatments of severe pneumonia with GCs have been developing for years with inconclusive results. In many cases GCs have been administered empirically without clinical evidence. Recent studies assess beneficial impact on treatment of severe pneumonia by suggesting specific dosage, period of administration, and tapered dosage. |
| format | Article |
| id | doaj-art-4596b346a2c6412b86e6ac1895b57f40 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4596b346a2c6412b86e6ac1895b57f402025-02-03T06:05:05ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/865635865635Glucocorticosteroid in Treatment of Severe PneumoniaFelinda Ariani0Kaixiong Liu1Zhang Jing2Jieming Qu3Department of Respiratory Medicine, Huadong Hospital, Shanghai Medical School of Fudan University, 221 Yananxi Road, Shanghai 200040, ChinaDepartment of Respiratory Disease, The First Affiliated Hospital, Fujian Medical University, 20 Chazhong Road, Fuzhou 350005, ChinaDepartment of Pulmonary Medicine, Zhongshan Hospital, Shanghai Medical School of Fudan University, 180 Fenglin Road, Shanghai 200032, ChinaDepartment of Respiratory Medicine, Huadong Hospital, Shanghai Medical School of Fudan University, 221 Yananxi Road, Shanghai 200040, ChinaAirway diseases such as pneumonia constitute a major health burden on a global scale; untreated pneumonia may develop to severe pneumonia and consequently lead to to fatal episodes of mortality and morbidity. The balance between inflammatory mediators is key for the outcome of the pulmonary infection; elimination of invading pathogen was marked by the release of cytokines and other inflammatory mediators from alveolar macrophages and glucocorticoid steroids (GCs) acting on the inflammatory component. Treatments of severe pneumonia with GCs have been developing for years with inconclusive results. In many cases GCs have been administered empirically without clinical evidence. Recent studies assess beneficial impact on treatment of severe pneumonia by suggesting specific dosage, period of administration, and tapered dosage.http://dx.doi.org/10.1155/2013/865635 |
| spellingShingle | Felinda Ariani Kaixiong Liu Zhang Jing Jieming Qu Glucocorticosteroid in Treatment of Severe Pneumonia Mediators of Inflammation |
| title | Glucocorticosteroid in Treatment of Severe Pneumonia |
| title_full | Glucocorticosteroid in Treatment of Severe Pneumonia |
| title_fullStr | Glucocorticosteroid in Treatment of Severe Pneumonia |
| title_full_unstemmed | Glucocorticosteroid in Treatment of Severe Pneumonia |
| title_short | Glucocorticosteroid in Treatment of Severe Pneumonia |
| title_sort | glucocorticosteroid in treatment of severe pneumonia |
| url | http://dx.doi.org/10.1155/2013/865635 |
| work_keys_str_mv | AT felindaariani glucocorticosteroidintreatmentofseverepneumonia AT kaixiongliu glucocorticosteroidintreatmentofseverepneumonia AT zhangjing glucocorticosteroidintreatmentofseverepneumonia AT jiemingqu glucocorticosteroidintreatmentofseverepneumonia |