A Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantification of Cystic Fibrosis Drugs (Caftors) in Plasma and Its Application for Therapeutic Monitoring

A Liquid Chromatography-Tandem Mass Spectrometry Method for the Quantification of Cystic Fibrosis Drugs (Caftors) in Plasma and Its Application for Therapeutic Monitoring

Cystic fibrosis (CF) is a life-threatening disorder caused by mutations in the CFTR gene, leading to defective chloride ion transport and thickened mucus in the respiratory and gastrointestinal systems. CFTR modulators, including ivacaftor, lumacaftor, tezacaftor, and elexacaftor, have improved pati...

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Bibliographic Details
Main Authors: Valentina D’Atri, Fabrizio Corrado, François Versace, Susana Alves Saldanha, Thomas Mercier, Monia Guidi, Paul Thoueille, Sylvain Blanchon, Angela Koutsokera, Michael Vogeser, Catia Marzolini, François Girardin, Georgia Mitropoulou, Zisis Balmpouzis, Isabelle Rochat, Alain Sauty, Laurent Arthur Decosterd, Eva Choong
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Molecules
Subjects:
cystic fibrosis
CFTR modulators
therapeutic drug monitoring
LC-MS/MS
pharmacokinetics
precision medicine
Online Access:https://www.mdpi.com/1420-3049/30/9/1866
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