An ureido-substituted benzenesulfonamide carbonic anhydrase inhibitor exerts a potent antitumor effect in vitro and in vivo

An ureido-substituted benzenesulfonamide carbonic anhydrase inhibitor exerts a potent antitumor effect in vitro and in vivo

Abstract Carbonic anhydrase IX (CA IX) is a tumor-specific metallo-enzyme upregulated during hypoxic conditions and implicated in several pathophysiological processes where tissue pH regulation is required such as cancer, cell invasion, metastatic and stem-like features, drug resistance and recurren...

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Main Authors: Giorgia Gazzaroli, Camilla Tavani, Serena Filiberti, Maria Luisa Massardi, Marta Turati, Giulia Garattini, Thomas S. Peat, Giuseppe Pieraccini, Andrea Angeli, Claudiu T. Supuran, Fabrizio Carta, Arianna Giacomini, Roberto Ronca
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Experimental Hematology & Oncology
Subjects:
Carbonic anhydrase inhibitor
Cancer therapy
Metastasis
Benzenesulfonamide
Online Access:https://doi.org/10.1186/s40164-025-00690-z
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https://doi.org/10.1186/s40164-025-00690-z

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