Comparison of large single and small multiple doses of cyclophosphamide exposure in mice during early prepubertal age on fertility outcome

Comparison of large single and small multiple doses of cyclophosphamide exposure in mice during early prepubertal age on fertility outcome

Abstract Cyclophosphamide (CY) exposure is known to affect the ovary and impair fertility. Clinically, treatment is generally given over multiple doses, but research models have generally used single doses. The relative effects of administering multiple small doses of CY in the prepubertal period ar...

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Main Authors: Sujith Raj Salian, Akshatha Daddangadi, Dhakshanya Predheepan, Divya Deeleep Bhagat Amonkar, Riddhi Kirit Pandya, Sindhura Lakshmi Koulmane Laxminarayana, Shubhashree Uppangala, Guruprasad Kalthur, Richard A. Anderson, Satish Kumar Adiga
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Cyclophosphamide
Female infertility
Fertility preservation
Ovarian follicle reserve
Ovulation
Postnatal mortality
Online Access:https://doi.org/10.1038/s41598-024-82264-3
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https://doi.org/10.1038/s41598-024-82264-3

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