Intranasal Administration of Acetaminophen-Loaded Poly(lactic-<i>co</i>-glycolic acid) Nanoparticles Increases Pain Threshold in Mice Rapidly Entering High Altitudes

Intranasal Administration of Acetaminophen-Loaded Poly(lactic-<i>co</i>-glycolic acid) Nanoparticles Increases Pain Threshold in Mice Rapidly Entering High Altitudes

<b>Background/Objectives:</b> Orally or intravenously administered acetaminophen experiences considerable liver first-pass elimination and may cause liver/kidney damage. This work examined the pharmacological effects of acetaminophen-loaded poly(lactic-<i>co</i>-glycolic acid...

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Bibliographic Details
Main Authors: Qingqing Huang, Xingyue Han, Jin Li, Xilin Li, Xin Chen, Jianwen Hou, Sixun Yu, Shaobing Zhou, Gu Gong, Haifeng Shu
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceutics
Subjects:
acetaminophen
poly(lactic-<i>co</i>-glycolic acid)
nanoparticle
intranasal administration
plateau
pain threshold
Online Access:https://www.mdpi.com/1999-4923/17/3/341
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