APOBEC3 Proteins: From Antiviral Immunity to Oncogenic Drivers in HPV-Positive Cancers

APOBEC3 Proteins: From Antiviral Immunity to Oncogenic Drivers in HPV-Positive Cancers

The human APOBEC superfamily consists of eleven cytidine deaminase enzymes. Among them, APOBEC3 enzymes play a dual role in antiviral immunity and cancer development. APOBEC3 enzymes, including APOBEC3A (A3A) and APOBEC3B (A3B), induce mutations in viral DNA, effectively inhibiting viral replication...

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Bibliographic Details
Main Authors: Eliza Pizarro Castilha, Rosalba Biondo, Kleber Paiva Trugilo, Giulia Mariane Fortunato, Timothy Robert Fenton, Karen Brajão de Oliveira
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Viruses
Subjects:
deamination
APOBEC
cancer
HPV
Online Access:https://www.mdpi.com/1999-4915/17/3/436
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