USP29 alleviates the progression of MASLD by stabilizing ACSL5 through K48 deubiquitination

USP29 alleviates the progression of MASLD by stabilizing ACSL5 through K48 deubiquitination

Background/Aims Metabolic dysfunction–associated steatotic liver disease (MASLD) is a chronic liver disease characterized by hepatic steatosis. Ubiquitin-specific protease 29 (USP29) plays pivotal roles in hepatic ischemia-reperfusion injury and hepatocellular carcinoma, but its role in MASLD remain...

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Main Authors: Sha Hu, Zhouxiang Wang, Kun Zhu, Hongjie Shi, Fang Qin, Tuo Zhang, Song tian, Yanxiao Ji, Jianqing Zhang, Juanjuan Qin, Zhigang She, Xiaojing Zhang, Peng Zhang, Hongliang Li
Format: Article
Language:English
Published: Korean Association for the Study of the Liver 2025-01-01
Series:Clinical and Molecular Hepatology
Subjects:
usp29 protein, human
metabolic dysfunction-associtaed steatotic liver disease
acsl5 protein, human
lipid metabolism disorders
Online Access:http://e-cmh.org/upload/pdf/cmh-2024-0478.pdf
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