IL-2 Complex Therapy Mitigates Humoral Rejection of Fully Mismatched Skin Allografts by Inhibiting IgG Alloantibody Formation

IL-2 Complex Therapy Mitigates Humoral Rejection of Fully Mismatched Skin Allografts by Inhibiting IgG Alloantibody Formation

Antibody-mediated rejection (ABMR) caused by donor-specific Abs (DSAs) is still the leading cause of late graft loss following clinical organ transplantation, and effective strategies to combat ABMR are still elusive. We previously showed that rIL-2 complexed with anti-IL-2 mAb clone JES6-1A12 (IL-2...

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Main Authors: Konstantinos Mengrelis, Mario Wiletel, Romy Steiner, Anna M. Weijler, Laurenz Wolner, Valentina Stolz, Milos Nikolic, Daniel Simon, Florian Frommlet, Jonathan Sprent, Hannes Stockinger, Nina Pilat
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
transplantation
regulatory T cells
germinal center
donor-specific antibodies
humoral tolerance
Online Access:https://www.mdpi.com/2073-4409/14/14/1086
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