Beyond biochemical patterning: How mechanical bistability governs robust organoid morphogenesis
Understanding the regulatory mechanisms of intestinal organoid morphogenesis remains a fundamental challenge in organoid biology. Emerging evidence highlights mechanical bistability as a critical regulator, mediated by dynamic lumen-actomyosin feedback. The recently developed 3D vertex model demonst...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Mechanobiology in Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949907025000221 |
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| author | Qigan Gao Yuehua Yang Haoxiang Yang Hongyuan Jiang |
| author_facet | Qigan Gao Yuehua Yang Haoxiang Yang Hongyuan Jiang |
| author_sort | Qigan Gao |
| collection | DOAJ |
| description | Understanding the regulatory mechanisms of intestinal organoid morphogenesis remains a fundamental challenge in organoid biology. Emerging evidence highlights mechanical bistability as a critical regulator, mediated by dynamic lumen-actomyosin feedback. The recently developed 3D vertex model demonstrates that crypt curvature modulates actomyosin localization via mechanosensitive pathways, creating two stable morphological states—bulged or budded—depending on mechanical history. This model advances beyond static vertex models by incorporating epithelial thickness variations and lumen pressure effects, explaining previously unresolved phenomena like irreversible crypt budding and snap-through transitions. The findings establish a new framework for understanding mechanical decision-making in epithelial tissues, with implications for organoid engineering and developmental biology. |
| format | Article |
| id | doaj-art-4559b35f19314b7aadaf9da35ac3cea4 |
| institution | Kabale University |
| issn | 2949-9070 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Mechanobiology in Medicine |
| spelling | doaj-art-4559b35f19314b7aadaf9da35ac3cea42025-08-20T03:31:07ZengElsevierMechanobiology in Medicine2949-90702025-06-013210013410.1016/j.mbm.2025.100134Beyond biochemical patterning: How mechanical bistability governs robust organoid morphogenesisQigan Gao0Yuehua Yang1Haoxiang Yang2Hongyuan Jiang3CAS Key Laboratory of Mechanical Behavior and Design of Materials, CAS Center for Excellence in Complex System Mechanics, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230026, ChinaCAS Key Laboratory of Mechanical Behavior and Design of Materials, CAS Center for Excellence in Complex System Mechanics, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230026, ChinaCAS Key Laboratory of Mechanical Behavior and Design of Materials, CAS Center for Excellence in Complex System Mechanics, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230026, ChinaCorresponding author.; CAS Key Laboratory of Mechanical Behavior and Design of Materials, CAS Center for Excellence in Complex System Mechanics, Department of Modern Mechanics, University of Science and Technology of China, Hefei, Anhui, 230026, ChinaUnderstanding the regulatory mechanisms of intestinal organoid morphogenesis remains a fundamental challenge in organoid biology. Emerging evidence highlights mechanical bistability as a critical regulator, mediated by dynamic lumen-actomyosin feedback. The recently developed 3D vertex model demonstrates that crypt curvature modulates actomyosin localization via mechanosensitive pathways, creating two stable morphological states—bulged or budded—depending on mechanical history. This model advances beyond static vertex models by incorporating epithelial thickness variations and lumen pressure effects, explaining previously unresolved phenomena like irreversible crypt budding and snap-through transitions. The findings establish a new framework for understanding mechanical decision-making in epithelial tissues, with implications for organoid engineering and developmental biology.http://www.sciencedirect.com/science/article/pii/S2949907025000221Mechanical bistabilityIntestinal organoidsVertex modelMorphogenesisEpithelial mechanics |
| spellingShingle | Qigan Gao Yuehua Yang Haoxiang Yang Hongyuan Jiang Beyond biochemical patterning: How mechanical bistability governs robust organoid morphogenesis Mechanobiology in Medicine Mechanical bistability Intestinal organoids Vertex model Morphogenesis Epithelial mechanics |
| title | Beyond biochemical patterning: How mechanical bistability governs robust organoid morphogenesis |
| title_full | Beyond biochemical patterning: How mechanical bistability governs robust organoid morphogenesis |
| title_fullStr | Beyond biochemical patterning: How mechanical bistability governs robust organoid morphogenesis |
| title_full_unstemmed | Beyond biochemical patterning: How mechanical bistability governs robust organoid morphogenesis |
| title_short | Beyond biochemical patterning: How mechanical bistability governs robust organoid morphogenesis |
| title_sort | beyond biochemical patterning how mechanical bistability governs robust organoid morphogenesis |
| topic | Mechanical bistability Intestinal organoids Vertex model Morphogenesis Epithelial mechanics |
| url | http://www.sciencedirect.com/science/article/pii/S2949907025000221 |
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