Beyond biochemical patterning: How mechanical bistability governs robust organoid morphogenesis

Understanding the regulatory mechanisms of intestinal organoid morphogenesis remains a fundamental challenge in organoid biology. Emerging evidence highlights mechanical bistability as a critical regulator, mediated by dynamic lumen-actomyosin feedback. The recently developed 3D vertex model demonst...

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Bibliographic Details
Main Authors: Qigan Gao, Yuehua Yang, Haoxiang Yang, Hongyuan Jiang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Mechanobiology in Medicine
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Online Access:http://www.sciencedirect.com/science/article/pii/S2949907025000221
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