A Broad-Spectrum Chemokine Inhibitor Drives M2 Macrophage Polarization Through Modulation of the Myometrial Secretome

A Broad-Spectrum Chemokine Inhibitor Drives M2 Macrophage Polarization Through Modulation of the Myometrial Secretome

The uterine smooth muscle (myometrium) is an immunomodulatory tissue capable of secreting multiple chemokines during pregnancy. We propose that before term labor, chemokines secreted as a result of mechanical stretch of the uterine walls by the growing fetus(es) induce infiltration of maternal monoc...

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Bibliographic Details
Main Authors: Adam Boros-Rausch, Anna Dorogin, Lubna Nadeem, Oksana Shynlova, Stephen James Lye
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
uterus
myometrium
pregnancy
labor
mechanical stretch
broad spectrum chemokine inhibitor
Online Access:https://www.mdpi.com/2073-4409/14/7/514
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