The type I collagen paradox in PDAC progression: microenvironmental protector turned tumor accomplice

Abstract Type I collagen (Collagen I, Col I), a principal component of the tumor extracellular matrix (ECM) that accounts for 80% of total ECM collagen, has emerged as a crucial factor in tumor biology. Recent research has found that Col I has influenced tumor growth, invasion, migration, and progno...

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Bibliographic Details
Main Authors: Qian Li, Cheng Yang, Junqiang Li, Ronglin Wang, Jie Min, Yang Song, Haichuan Su
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Online Access:https://doi.org/10.1186/s12967-025-06778-8
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