Metabolic mutations reduce antibiotic susceptibility of E. coli by pathway-specific bottlenecks

Metabolic mutations reduce antibiotic susceptibility of E. coli by pathway-specific bottlenecks

Abstract Metabolic variation across pathogenic bacterial strains can impact their susceptibility to antibiotics and promote the evolution of antimicrobial resistance (AMR). However, little is known about how metabolic mutations influence metabolism and which pathways contribute to antibiotic suscept...

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Main Authors: Paul Lubrano, Fabian Smollich, Thorben Schramm, Elisabeth Lorenz, Alejandra Alvarado, Seraina Carmen Eigenmann, Amelie Stadelmann, Sevvalli Thavapalan, Nils Waffenschmidt, Timo Glatter, Nadine Hoffmann, Jennifer Müller, Silke Peter, Knut Drescher, Hannes Link
Format: Article
Language:English
Published: Springer Nature 2025-01-01
Series:Molecular Systems Biology
Subjects:
Metabolism
Antibiotic Resistance
Mutations
Escherichia coli
CRISPR
Online Access:https://doi.org/10.1038/s44320-024-00084-z
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https://doi.org/10.1038/s44320-024-00084-z

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