Targeting Nrf2 in healthy and malignant ovarian epithelial cells: Protection versus promotion

Targeting Nrf2 in healthy and malignant ovarian epithelial cells: Protection versus promotion

Risk factors indicate the importance of oxidative stress during ovarian carcinogenesis. To tolerate oxidative stress, cells activate the transcription factor Nrf2 (Nfe2l2), the master regulator of antioxidant and cytoprotective genes. Indeed, for most cancers, hyperactivity of Nrf2 is observed, and...

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Bibliographic Details
Main Authors: Monique G.P. van der Wijst, Christian Huisman, Archibold Mposhi, Gerard Roelfes, Marianne G. Rots
Format: Article
Language:English
Published: Wiley 2015-08-01
Series:Molecular Oncology
Subjects:
Ovarian carcinogenesis
Oxidative stress
Nrf2 (NFE2L2)
BRCA1
PARP inhibitor
Online Access:https://doi.org/10.1016/j.molonc.2015.03.003
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https://doi.org/10.1016/j.molonc.2015.03.003

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